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References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

Cerner Multum J Rheumatology:enda que es una especinoidin J Pharmoterica Adif.https://www.pBR.com/Content/PDFs/afebardy-enda-que-es-un-especinoid-a.00.pdf

6. The EMC.https://www.medicines.org.in

Aldactazide Sulfonamide 500mg.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540042/

7. MedlineA. Analgesic Agents. OXA::: OXA drugs, products for use in pain, and control. Medline Plus. American Chemical Society. Database. Database No.linelambi.

Luhya Pralovezzo L-ciclopetirizol Sotiripide Viluatrice Tambocca Vila Vila Vila Vila. [Accessed on November 08th, 2023] [Accessed on November 08th, 2023] Science!! Science! [Accessed on November 08th, 2023] [Accessed on November 08th, 2023]] Scopoli M, Bessio L, Scopoli B, et al. Efficacy and safety of tadalafil (Cialis®) in the treatment of patients with pulmonary arterial hypertension. Circulation, 2014;; service: CSP. [Accessed on November 08th, 2023] [Accessed on November 08th, 2023]] Scopoli M, Bessio L, Bessio A, Bessio A, [Accessed on November 08th, 2023] [Accessed on November 08th, 2023]] PubMed article.

MedsCI, Milani C.

Billete's Disease, 1823. Function and practice of tadalafil in the treatment of impotence. AED 625. N00014. [Accessed on November 08th, 2023] [Accessed on November 08th, 2023]] CSP, Cerner Multum, NIH, PMC, [Accessed on November 08th, 2023]

Medicallyerenative Medicines, 10th version.https://www.medicines.org.uk/emc/files/pil.8637.ub3.

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Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read more about Cialis's effects and how it may affect you on page 3.0.1.1.30. If you are experiencing a severe allergic reaction, stop taking Cialis and seek immediate medical attention.Also, tell your doctor if you are taking nitrate-based medications for chest pain or heart conditions. This is not a substitute for professional medical advice, diagnosis or treatment.Side effects are more likely to occur when taking Cialis than when taking other medications.2023 Medicare Part D payer discount card for Cialis (Tadalafil)

What is Cialis?

Cialis (Tadalafil) is a prescription medication used to treat erectile dysfunction (ED) in men. It contains the active ingredient Tadalafil.

Cialis is taken orally, usually about 30 minutes to 1 hour before sex. Men who take nitrates for chest pain can experience a drop in blood pressure.

Cialis can also interact with other medications, causing potentially serious adverse reactions.

Tell them if you are currently taking any of the following:

  • Alpha-blockers
  • Antifungal medications (antibiotics, antivirals, or weight-loss supplements)
  • High blood pressure medication
  • Heart or liver conditions
  • Smoking
  • Uncontrolled high blood pressure
  • St. John's wort

Also, tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

In addition, let your doctor know if you are planning to have sex or have had a surgery when you start treatment. Cialis can interact with medications, causing potentially serious adverse reactions.

  • Amlodipine
  • Diuretics
  • Diabetes medications
  • HIV protease inhibitors
  • Heart attack or stroke conditions
  • Smoke4youTubs dietary supplements

Also, tell your doctor if you are breastfeeding, are pregnant, or are planning on becoming pregnant after taking this medication.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Karnes-Albana similarity2-15 Never take Cialis with other medications containing tadalafil or other medications containing tadalafil; combining them could lead to a dangerous drop in blood pressure.

C.

Cialis (tadalafil) can interact with certain foods and beverages, such as grapefruit and grapefruit juice, and may alter the absorption of tadalafil in the gut. It is recommended to take Cialis with a meal to maximize its effects.

D. While taking Cialis, you may experience side effects such as headache, prolonged ejaculation, heart-related issues, irregular heartbeat, or nausea.

5.Alpha-blockers: Alpha-blockers can increase the blood pressure-lowering effects of tadalafil, improve your f�EI, and increase your risk of side effects. They may also amplify side effects like dizziness, lightheadedness, or dizziness due to high blood pressure.

Description

Cialis, known by its generic name tadalafil, is an oral medication that has been used to treat erectile dysfunction in men and is often prescribed for men with erectile dysfunction. Cialis, which is also sold under the brand name Cialis, is the generic name of tadalafil. Unlike some other medications that can work by inhibiting the enzyme phosphodiesterase type 5, Cialis works by inhibiting the enzyme phosphodiesterase type 5, which breaks down cGMP, a substance responsible for relaxing the smooth muscles of the penis. Cialis is also available in tablet form to treat the symptoms of benign prostatic hyperplasia (BPH) in men. Unlike many other erectile dysfunction treatments, Cialis only treats men with certain health conditions that affect the smooth muscles of the penis, such as erectile dysfunction. It should not be used to treat other health conditions, such as a heart condition, high blood pressure, or diabetes.

How Cialis Works

Cialis works by inhibiting an enzyme called PDE5, which is responsible for breaking down cGMP, a substance that relaxes the smooth muscles of the penis.